Sisters of Wellber is a fantasy anime series animated by Trans Arts. Directed by Takayuki Hamana, the director behind the renowned Prince of Tennis TV series and animated movies, Sisters of Wellber began airing in Japan on Tokyo MX, Mētele, ABC, and AT-X in April 2007.

A related manga, MUZZLE-LOADER 〜Wellber Stories〜, has begun serialization on February 28, 2007 in Monthly Comic Blade, one of Mag Garden's magazines.

A second season started on January 1, 2008, picking up just where the first season left off.