Mula sa Puso is a Filipino television series originally aired by ABS-CBN from March 10, 1997 to April 9, 1999. Claudine Barretto, Rico Yan, and Diether Ocampo played the roles of the main protagonists in the series. It was re-aired in 2008 through Studio 23 and Kapamilya Channel, which are both ABS-CBN subsidiaries. A 2011 remake, starring Lauren Young, JM De Guzman and Enrique Gil, aired on ABS-CBN from March 28, 2011 to August 12, 2011.

The show also gave critical acclaim to director Wenn V. Deramas as his first prime time soap project and as a director and gave character actress Princess Punzalan critical acclaim for her character and antagonist as the phenomenal Selina Perriera-Matias which was also reincarnated again for the television remake by award-winning soap actress Eula Valdez. It was also known for being the most competitive soap, tied with Esperanza, which also ran from 1997 to 1999 and also spanned a film and a soundtrack entitled "Mula Sa Puso ni Esperanza" the TV series had various crossovers with prime time dramas such as Esperanza and the short-lived Mini series Sa Sandaling Kailangan Mo Ako.