Ever since moving to Great Lakes City in The Loudest Mission: Relative Chaos (2017), Ronnie Anne and Bobby will adjust to their new life in the city, where they now live with their big, loving, chaotic multi-generational family, the Casagrandes. Ronnie Anne will make new friends, build stronger bonds with her relatives, and explore the endless possibilities of city life. Bobby helps Abuelo run the Mercado and meets all the city neighbors who shop there. Ronnie Anne and Bobby deal with their parents' divorce, their mom always working shifts as a nurse at the hospital, and their dad working as a doctor in Peru.